CJC-1295 no DAC (Mod GRF 1-29)

  5-amino-1MQ is a small molecule that blocks the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). NNMT is a very important component in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as the "longevity gene" because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer. Research in mice given 5-amino-1MQ showed a 7% reduction in body mass over 10 days without any changes in food intake, compared to controls. Research has shown that decreasing NNMT may help shrink fat cells and reduce the size of fat deposits.

Epithalon (Epitalon) has long been understood to help preserve telomeres, which are the protective end caps found on fragments of DNA (chromosomes). Telomeres protect DNA from degradation as it is replicated during cell division (one cell splitting into two). Telomeres themselves suffer degradation, however, and eventually become too short to be effective. At this point, a cell will either commit cell suicide in a process called apoptosis or it will go dormant in a process called senescence. Both processes lead to aging and eventual dysfunction and disease. Senescence is one of the primary drivers of disease and aging. Epitalon has been shown to activate an enzyme called telomerase, which protects and repairs telomeres. More active telomerase means that cells age slower and remain functional longer. The net result is that overall aging appears to be slowed down. Research in rodents indicates that Epitalon may extend life by as much as 27% via this mechanism[2], [3]. Epitalon does not only activate telomerase. As noted above, Epitalon has been shown to affect expression for several genes through alteration of DNA structure. This process, called epigenetic modification, is of interest to scientists because it provides the foundation for controlling gene expression at a very fine level. Research is being conducted to learn how to harness epigenetic technology, which could potentially allow scientists to alter everything from an individual’s eye color to how intelligent a person is or how long someone lives. Micro-encapsulated Epitalon has shown excellent orally bioavailability in lab research studies.

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme in all living cells, essential for metabolic processes and cellular function. It acts as a mediator of redox reactions, alternating between its oxidized (NAD+) and reduced (NADH) forms to facilitate electron transfer, crucial for energy production and sustaining life. Involved in over 500 enzymatic reactions, NAD+ is central to maintaining cellular homeostasis. Research shows that NAD+ may be beneficial in improving muscle function, protecting cells of the nervous system, and generally reducing the effects of aging.

Beyond energy metabolism, NAD+ supports DNA repair and gene regulation through enzymes like sirtuins and PARPs. Sirtuins use NAD+ to regulate cellular functions such as DNA repair, gene expression, and aging, while PARPs utilize it to repair DNA damage and maintain genomic stability. These roles underscore NAD+'s importance in cellular integrity and combating aging.